资源元数据详细信息

Asialo-transferrin from human cerebrospinal fluid was purified to homogeneity. Investigation of the structural characteristics of its oligosaccharides support our hypothesis of 'brain-type' glycosylation of intrathecally synthesized cerebrospinal fluid proteins. For carbohydrate structural analysis, high-pH anion-exchange chromatography, methylation analysis, liquid secondary ion- and matrix-assisted laser desorption/ ionization mass spectrometry of the permethylated derivatives were used. The major structure turned out to be a complex-type agalactodiantennary oligosaccharide with bisecting N-acetylglucosamine and proximal fucose. Analysis of a second transferrin preparation containing both asialo- and sialo-transferrin revealed another major glycan species derived from the sialylated transferrin variant which is galactosylated and lacks bisecting N-acetylglucosamine and fucose.

语种：

英语

格式：

html

资源集合类型：

科学数据

内容类型：

数据集

学科分类：

Biology and Life Sciences ; biochemical research methods ; biochemistry ＆ molecular biology ;

中文关键词：

生物化学生物信息学碳水化合物序列脑脊液唾液酸 N-糖基糖链结构

英文关键词：

Biochemistry; Bioinformatics; Carbohydrate sequence; Mankind; Cerebrospinal fluid; Sialic acid; N-glycosylation; Sugar chain structure;

版权信息：

Copyright. Macquarie University (Biomolecular Frontiers Research Centre), Australia; Proteome Informatics Group (Swiss Institute for Bioinformatics)

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适用对象：

学生科研工作者教师

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使用权限：

UniCarb-DB is open source platform and an open access resource. The resources published via the platform need to be referenced when used. For example: UniCarb-DB, http://www.unicarb-db.org last accessed: dd/mm/yyyy. with citation

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3276

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登记时间：

2012-10-30 10:47:20.0

修改时间：

2013-05-02 10:08:01.0

URL最后检查时间：

2017-07-24 01:02:03.0

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