资源名称:
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′Brain-type′ N-glycosylation of asialo-transferrin from human cerebrospinal fluid
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URL:
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http://researchdata.ands.org.au/brain-type-n-glyco
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资源描述:
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Asialo-transferrin from human cerebrospinal fluid was purified to homogeneity. Investigation of the structural characteristics of its oligosaccharides support our hypothesis of 'brain-type' glycosylation of intrathecally synthesized cerebrospinal fluid proteins. For carbohydrate structural analysis, high-pH anion-exchange chromatography, methylation analysis, liquid secondary ion- and matrix-assisted laser desorption/ ionization mass spectrometry of the permethylated derivatives were used. The major structure turned out to be a complex-type agalactodiantennary oligosaccharide with bisecting N-acetylglucosamine and proximal fucose. Analysis of a second transferrin preparation containing both asialo- and sialo-transferrin revealed another major glycan species derived from the sialylated transferrin variant which is galactosylated and lacks bisecting N-acetylglucosamine and fucose.
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语种:
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英语
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格式:
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html
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资源集合类型:
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科学数据
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内容类型:
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数据集
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学科分类:
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Biology and Life Sciences
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biochemical research methods
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biochemistry & molecular biology
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中文关键词:
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生物化学
生物信息学
碳水化合物序列
脑脊液
唾液酸
N-糖基
糖链结构
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英文关键词:
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Biochemistry;
Bioinformatics;
Carbohydrate sequence;
Mankind;
Cerebrospinal fluid;
Sialic acid;
N-glycosylation;
Sugar chain structure;
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版权信息:
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Copyright. Macquarie University (Biomolecular Frontiers Research Centre), Australia; Proteome Informatics Group (Swiss Institute for Bioinformatics)
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更新方式:
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创建
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更新周期:
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不定期
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适用对象:
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学生 科研工作者 教师
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访问控制方式: |
开放获取
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使用权限: |
UniCarb-DB is open source platform and an open access resource. The resources published via the platform need to be referenced when used. For example: UniCarb-DB, http://www.unicarb-db.org last accessed: dd/mm/yyyy. with citation |
被访问次数: |
4023 |
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IRSR记录登记信息:
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来源: |
机器抓取
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登记时间: |
2012-10-30 10:47:20.0 |
修改时间: |
2013-05-02 10:08:01.0 |
URL最后检查时间: |
2020-08-11 01:10:54.0 |
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