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资源名称: ′Brain-type′ N-glycosylation of asialo-transferrin from human cerebrospinal fluid
URL: http://researchdata.ands.org.au/brain-type-n-glyco
资源描述:

Asialo-transferrin from human cerebrospinal fluid was purified to homogeneity. Investigation of the structural characteristics of its oligosaccharides support our hypothesis of 'brain-type' glycosylation of intrathecally synthesized cerebrospinal fluid proteins. For carbohydrate structural analysis, high-pH anion-exchange chromatography, methylation analysis, liquid secondary ion- and matrix-assisted laser desorption/ ionization mass spectrometry of the permethylated derivatives were used. The major structure turned out to be a complex-type agalactodiantennary oligosaccharide with bisecting N-acetylglucosamine and proximal fucose. Analysis of a second transferrin preparation containing both asialo- and sialo-transferrin revealed another major glycan species derived from the sialylated transferrin variant which is galactosylated and lacks bisecting N-acetylglucosamine and fucose.

语种: 英语   
格式: html   
资源集合类型: 科学数据
内容类型: 数据集
学科分类: Biology and Life Sciences biochemical research methods biochemistry & molecular biology
中文关键词: 生物化学 生物信息学 碳水化合物序列 脑脊液 唾液酸 N-糖基 糖链结构
英文关键词: Biochemistry; Bioinformatics; Carbohydrate sequence; Mankind; Cerebrospinal fluid; Sialic acid; N-glycosylation; Sugar chain structure;
版权信息: Copyright. Macquarie University (Biomolecular Frontiers Research Centre), Australia; Proteome Informatics Group (Swiss Institute for Bioinformatics)
更新方式: 创建
更新周期: 不定期
适用对象: 学生   科研工作者   教师   
访问控制方式: 开放获取
使用权限: UniCarb-DB is open source platform and an open access resource. The resources published via the platform need to be referenced when used. For example: UniCarb-DB, http://www.unicarb-db.org last accessed: dd/mm/yyyy. with citation
被访问次数: 3177

IRSR记录登记信息:
来源: 机器抓取
登记时间: 2012-10-30 10:47:20.0
修改时间: 2013-05-02 10:08:01.0
URL最后检查时间: 2017-07-24 01:02:03.0


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